ABSTRACT: No elevation in long-term breast carcinoma risk for
women with fibroadenomas that contain atypical hyperplasia
BACKGROUND: The authors previously showed that women with
a fibroadenoma have a relative risk of invasive breast carcinoma
of approximately 2.0 compared with women of similar age from
the general population.
This relative risk approaches 1.0 when
family history and proliferative changes in the adjacent parenchyma
are removed and rises to > 3.0 if the fibroadenoma has complex
The risk for developing breast carcinoma in women
with atypical lobular hyperplasia (ALH) and atypical ductal hyperplasia
(ADH) or their minimal variants within a fibroadenoma is unknown.
CONCLUSIONS: In this study of a large cohort of women with
fibroadenoma, the authors found that atypia within a fibroadenoma
cannot predict for the presence of atypia within adjacent breast
They also found that atypia confined to a fibroadenoma
does not incur a clinically meaningful risk of future breast
carcinoma development greater than that of fibroadenoma alone.
07/03/2001; Cancer Online
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