Estrogen Replacement after Ischemic Stroke
Some observational studies have suggested that women who are receiving estrogen-replacement therapy have a lower risk of stroke and death than others.
The Women's Estrogen for Stroke Trial was a double-blind, placebo-controlled trial of estradiol-17 in 664 women with a recent cerebrovascular event.
Estrogen therapy did not reduce the risk of stroke or death in these women and was associated with a borderline increase in the risk of fatal stroke; this therapy was also associated with adverse effects on the endometrium.
This study adds to the growing body of data from randomized trials that have failed to confirm a cardiovascular benefit of estrogen-replacement therapy. Estrogen should not be prescribed for the secondary prevention of cerebrovascular disease.
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