ER negative Tumors and Retinoids

Ann's NOTE: I must preface this paper by stating that I KNOW that Vitamin A (actually less toxic than 'retinoids' in any form), can raise ER positive status. This happened to me. I have spoken with several researchers and some prominent oncologists about the idea that Vitamin A use could help change ER negative tumors to ER positive. This is a human subjects trial I would LOVE to see).

The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice.

Wu K, Zhang Y, Xu XC, Hill J, Celestino J, Kim HT, Mohsin SK, Hilsenbeck SG, Lamph WW, Bissonette R, Brown PH.

Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA.

Despite the effectiveness of the selective estrogen receptor (ER) modulators in preventing ER-positive breast cancer, chemopreventive agents still need to be developed for the prevention of ER-negative breast cancers.

The naturally occurring retinoids are promising agents for the prevention of human cancers but are too toxic for long-term chronic use. We previously demonstrated that the chemopreventive effects of the retinoids could be separated from the toxicity by using an RXR-selective retinoid, LGD1069.

The studies described here demonstrate that LGD1069 effectively suppresses ER-negative tumor development in mouse mammary tumor virus-erbB2 transgenic mice with minimal toxicity.

These studies suggest that receptor-selective retinoids are promising agents for the prevention of breast cancer and that they may be particularly useful in preventing ER-negative breast cancer.

Cancer Res 2002 Nov 15;62(22):6376-80

Reverting ER- Pheotype in HER-s-Overexpressing BCA

Breast Cancer Res, 1/06

Discussion and Conclusions: Reverting Estrogen Negative BCa
References; Reverting ER- Breast Cancer

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