ABSTRACT: The effects of tricyclic antidepressants on breast cancer
To test the hypothesis that tricyclic antidepressant use increases
invasive female breast cancer incidence, we carried out a case-control
study within the population of female beneficiaries of the Saskatchewan
Prescription Drug Plan aged 35 years from 1981-1995 with
no history of cancer since 1970.
This agency has provided full
or partial coverage for outpatient prescriptions to Saskatchewan
residents since 1975. We accrued 5882 histologically proven cases
and 23 517 controls, randomly selected from the source population
and individually matched on age and sampling time.
to any tricyclic antidepressants was associated with an elevated
rate ratio for breast cancer 11-15 years later (2.02, 95%
confidence interval: 1.34-3.04). Post hoc analyses based
on the results of genotoxicity studies carried out using Drosophila
melanogaster suggested that the increased risk could be attributed
to the use of the six genotoxic tricyclic antidepressants, and
not to the use of the four nongenotoxic tricyclic antidepressants.
However, our results may have been confounded by the effects
of other determinants of breast cancer associated with tricyclic
[02/04/2002; British Journal of Cancer]
Thanks to breastcancer.net
Arch Gen Psychiatry, 12/02
The Holistic Dental Digest,
Canadian J Psychiatry, 2/03
J Am Geriatrics Soc, 1/04
Abstract # 6132
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