ABSTRACT: The utility of ductal lavage in breast cancer detection
and risk assessment
Ductal lavage (DL) permits noninvasive retrieval of epithelial
cells from the breast.
Clinical development of this technique
has been fueled largely by its potential, as yet unproven, to
improve detection of breast cancer and definition of individual
risk for development of breast cancer. Early studies demonstrate
the feasibility of performing this technique, provide data on
cellular yield and findings, and demonstrate the ability to
measure molecular markers in DL fluid.
However, the sensitivity
and specificity of DL for the detection of breast cancer remains
unknown, as does the significance of atypia, particularly mild
atypia, when found in DL fluid. Although DL appears safe and
the device is approved by the US Food and Drug Administration,
DL is still best utilized in the setting of clinical trials
designed to resolve issues of sensitivity, specificity, and
[02/25/2002; Breast Cancer Research]
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