Direct effects of bisphosphonates on breast cancer cells
Siddhika G Senaratne, Kay W Colston
Department of Oncology, Gastroenterology, Endocrinology, and Metabolism, St George's Hospital Medical School, Cranmer Terrace, London, UK.
© 2002 BioMed Central Ltd (Print ISSN 1465-5411 | Online ISSN 1465-542X)
In addition to inhibiting bone resorption, bisphosphonates have also been shown to exhibit antitumour effects. In vitro, bisphosphonates inhibit proliferation and induce apoptosis in cultured human breast cancer cells. In addition, bisphosphonate treatment interferes with breast cancer cell adhesion to bone matrix, and inhibits cell migration and invasion.
The combination of bisphosphonates with other anticancer drugs such as the taxoids markedly enhances these effects.
These newly recognized direct actions of bisphosphonates on breast cancer cells indicate that these agents may have a greater role to play in treatment of patients suffering from cancers with a propensity to metastasize to bone.
Breast Cancer Research 2002, 4: 18-23
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