ABSTRACT: Influence of Physical Activity in Different Age and
Life Periods on the Risk of Breast Cancer
We conducted a population-based case-control study of 1,237 incident
breast cancer cases and 1,241 controls in Alberta between 1995
and 1997 to examine the effect of physical activity performed
at different ages and life periods on breast cancer risk.
this study, we measured all types of physical activity done throughout
life with a questionnaire developed and tested specifically for
this study. We found that breast cancer risk was most associated
with a risk reduction for activity done later in life, particularly
between menopause and the reference year, for which we observed
an odds ratio of 0.70 (95% confidence interval = 0.52-0.95).
We also stratified the study participants into four categories
according to their patterns of physical activity performed before
and after menopause.
For the women who sustained physical activity
throughout life vs those who were never active, we found an odds
ratio of 0.58 (95% confidence interval = 0.41-0.83).
This study suggests that sustained activity throughout life and
particularly activity done later in life may have the most benefit
in reducing breast cancer risk.
Epidemiology 2001 November;12(6):604-612
Cancer Epidem Biomarkers & Preventn, 2/07
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