#C141 Diet, Supplemental Use, and Breast Cancer: The Role of Vitamin D.
Shenade M. Walker,1 Julia A. Knight,1 Joseph Beyene,2 Michelle Cotterchio,3 Esther M. John.4
Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital,1 Toronto, ON, Canada, Programme in Population Health Sciences, Research Institute, Hospital for Sick Children,2 Toronto, ON, Canada, Division of Preventive Oncology, Cancer Care Ontario,3 Toronto, ON, Canada, Northern California Cancer Center,4 Union City, CA.
Recent evidence suggests that vitamin D may protect against the development and progression of breast cancer (BC). However, the effects of vitamin D intake are understudied, and inconclusive results have been reported.
We investigated the relationship between dietary and supplemental vitamin D intake and BC risk at the Ontario site of the Breast Cancer Family Registry.
This study included 1,732 women with invasive BC identified from the Ontario Cancer Registry between 1996 and 1998, and 1,694 age-matched controls identified from randomly generated telephone lists who completed mailed questionnaires.
Using unconditional logistic regression we estimated odds ratios (OR) and 95% confidence intervals (CI), adjusting for sampling stratum, age, family history, ethnicity, and caloric intake.
Pre-menopausal women with the highest quartile of total vitamin D intake had reduced risk compared to the lowest quartile (OR=0.67, 95% CI 0.47-0.96). Among post-menopausal women, only supplement use reduced risk (OR=0.30, 95% CI 0.15-0.59) for >400 vs. 0 I.U./day.
There was a significant interaction (p=0.048) between total vitamin D intake and BMI among all women.
Both total vitamin D intake and supplement use >400 I.U./day decreased risk in women with BMI 25 kg/m2 (OR=0.59, 95% CI 0.41-0.85 and OR=0.33, 95% CI 0.15-0.73, respectively). No significant association was observed in all women combined with a BMI 2.
Vitamin D intake reduced the risk of BC in both pre and post-menopausal women, and when stratified by BMI, only in women with a BMI 25 kg/m2.
These findings are consistent with the hypothesis that vitamin D reduces the risk of developing BC.
Frontiers in Cancer Prevention Research, 2003
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