Diet and Lung Cancer Risk From a 14-Year Population-Based Prospective Study in Japan: With Special Reference to Fish Consumption
Toshiro Takezaki1; Manami Inoue2; Hiroki Kataoka3; Syuhei Ikeda4; Miyako Yoshida5; Yoko Ohashi6; Kazuo Tajima7; Suketami Tominaga8
N-3 polyunsaturated fatty acids in fish oil exhibit a variety of health benefits, and there is evidence that they can inhibit the development of human lung mucoepidermoid and other carcinomas.
To examine the hypothesis that fish consumption reduces the risk of lung cancer, we conducted a population-based prospective study, following 5,885 residents for 14 yr.
Person-years were used to calculate the relative risk (RR) by the Cox proportional hazards model, with adjustment for potential confounding factors.
A total of 51 incident lung cancer cases were observed, and we found linearly decreasing RRs for lung cancer with increased frequency of consumption of fish and shellfish (RRs = 1.00, 0.99, and 0.32, P for trend = 0.003) but not with intake of dried/salted fish.
Decreased RRs were apparent with both broiling and boiling cooking methods, but reduction with raw and deep-fried fish consumption was not statistically significant.
We conclude that frequent fresh fish consumption, irrespective of the cooking method, may reduce the risk of lung cancer.
Affiliations: 1: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan ; 2: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, and is affiliated with the Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Kashiwa 277-8577, Japan ; 3: Asuke Public Health Center (APHC), Higashikamo 444-2422, Japan ; 4: APHC, and is affiliated with the Iida Municipal Hospital Takamatsu Center Branch, Iida 395-8503, Japan ; 5: APHC, and is affiliated with the Aichi Prefectural Board of Education Office, Nagoya 460-8501, Japan ; 6: APHC, and is affiliated with the Inazawa Branch Office of the Ichinomiya Public Health Center, Inazawa 492-8216, Japan ; 7: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan ; 8: Aichi Cancer Center, 464-8681, Japan
Nutrition and Cancer Volume: 45 Number: 2 Page: 160 -- 167
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