Dietary Factors and Lung Ca Risk in 

Japanese (fish consumption)

June 2010

Evaluating daily exposure to polychlorinated biphenyls and polybrominated diphenyl ethers in fish oil supplements

Abstract Fish oil supplements have become a popular means of increasing one's dietary intake of essential polyunsaturated fatty acids. However, there is growing concern that the levels and potential health effects of lipophilic organic contaminants such as polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) may diminish some of the health benefits associated with the daily consumption of fish oil supplements.

In this study, ten over-the-counter fish oil supplements available in the United States were analysed for PCBs and PBDEs and daily exposures calculated. Based on manufacturers' recommended dosages, daily intakes of PCBs and PBDEs ranged from 5 to 686 ng day-1 and from 1 to 13 ng day-1, respectively. Daily consumption of fish oil supplements expose consumers to PCBs and PBDEs.

However, in comparison with fish ingestion, fish supplements may decrease daily PCB exposure and provide a safer pathway for individuals seeking to maintain daily recommended levels of polyunsaturated fatty acids.

Food Additives & Contaminants: Part A, Volume 27, Issue 8 August 2010 , pages 1177 - 1185

Dietary factors and lung cancer risk in Japanese: with special reference to fish consumption and adenocarcinomas

T. Takezaki, K. Hirose, M. Inoue, N. Hamajima, Y. Yatabe, T. Mitsudomi, T. Sugiura, T. Kuroishi, K. Tajima


To investigate risk modification for lung cancer with diet in Japanese, we conducted a hospital-based case-control study and evaluated variation in influence with the histological type. We recruited 367 male and 240 female cases with adenocarcinomas, and 381 male and 57 female cases with squamous cell and small cell carcinomas.

Controls comprised 2964 male and 1189 female cancer-free outpatients matched for sex and age with the cases. Odds ratios (ORs) and their 95% confidence intervals (CIs) for lung cancer were calculated with adjustment for potential confounding factors, using an unconditional logistic model.

We found decreased ORs for adenocarcinomas in both males (OR = 0.51, 95% CI 0.31-0.84) and females (OR = 0.48, 95% CI 0.24-0.94) who consumed cooked/raw fish, but not dried/salted fish at the highest quartile frequency, compared with the lowest. Soybean curd consumption was associated with a decreased OR for female adenocarcinomas.

Decreased ORs for squamous cell and small cell carcinomas were observed in males with frequent consumption of raw and green vegetables, fruit and milk, but consumption of carrot, pumpkin, egg and coffee was associated with increased ORs.

This study suggests cooked/raw fish consumption lowers the risk of adenocarcinoma of the lung in Japanese.

British Journal of Cancer p 1199-1206, Volume 84, Number 9, May 2001

Thanks to Ivanhoe Newswire for this information.

Fish consumption/cancer

Study in the American Journal of Clinical Nutrition

Fish Oil inhibits growth of human Papillomavirus
Fish Or Fish Oil
Fatty Acids: Fish Oils/Fish Kill Mitochondria
Fish Intake is Positively Assoc w/Bca Incidence
Methodological Weaknesses in Studies of Fish/Cancer
Fish Consumption Reduces Renal Cancer Risk
Omega 3 in Human Bca Cells -EPA/DHA

Breast Cancer Research & Treatment, 9/01

30% Fish Oil Conctrte &Efficacy of Doxorubicin (mice)
Gene Transfer can Increase N-3 to N-6 Ratio
Dietary N-3 and N-6 & Mammary Ca:Singapore Chinese
Safety considerations with omega-3 fatty acid therapy.
Fish Oil and Wasting (Cachexia)

Nutrition and Cancer, 2000 31 references

EPA used to stop Aspects of Cancer Cachexia
EPA Halts Cachexia Weight Loss
Fish Oil Supplementation: Advanced Cancer Pts
Cancer Cachexia & Tumor Growth Reduction-Omega 3
Omega-3 Adds Energy (Human Study)
Phase II Human Study High-dose Fish Oil & Cachexia
Fish Oil and Cachexia - During Chemo/HUMAN study
Reg of Tumor Angiogenesis by Dietary Fatty Acids &EPA

Nutrition and Cancer, 2000 Part I

Commentary and References (115)
Effects of Genistein & EPA

J Cancer Res Clin Oncol, 8/01

Wild vs Cultured Australian Abalone: More Omega-3

Int J Food Sciences & Nutr, 3/04

Short-Chain Fatty Acids Inhibit Colon Ca

J Nutrition, 2001

DHA and Apoptosis in Human Colon Ca cells
Omega-3 Cuts Cancer Risk
Dietary DHA Levels & Outcome of Chemo in Leukemic Mice
Study of Fish Oil and Garlic

Int'l J for Vitamin and Nutrition Research, 2001

FARM Fish Information

UPI, 9/02

Issues w/ Farm-raised Fish
Fish Farm Breeding Problems
Omega-3 Fatty Acids to Augment Cancer Therapy
Genetically Modified Fish Species:Ask if Wild or Farmed
Chemical Makes Fish Eat Vegetables Not Other Fish
Omega-3 Augments Cancer Chemo

J Nutr, 11/02 AICR July, 2002 Meeting abstract

Food Sources of Omega-3
DHA (Fish Oil) Downregulates Her-2/neu in Bca Cells
FDA Says Canned Light Tuna LESS Mercury

Science News Online, 3/04

Hair mercury levels in relation to fish consumption
Polyunsaturated Fatty Acids,Inflammation/Immunity

Euro J Clin Nutr, 8/02

Response to JAMA on Fish Oil

January 2006 Bill Sardi, Knowledge of Health

Press Release on Omega-3 Fatty Acids
Udo Erasmus

LINK to site for author of Fats that Heal, Fats that Kill

Carlson Laboratories

LINK to premiere company for fish oil and other supplements.

"Our product lines now include award-winning Norwegian fish oils, a full line of vitamins, minerals, amino acids, special formulations & nutritional supplements".

After Surgery Feeding w/Omega-3 Esophageal Cancer

J Parenter Enteral Nutr, 5-6/05

Study: Eat Normally After Esophageal Surgery
Omega-3 EPA preserves muscle mass AFTER Surgery
Nordic Naturals

LINK: "Nordic Naturals offers the world's finest Omega-3 fish oils from Norway. These award-winning formulas are pharmaceutical grade, doctor-recommended, and third-party tested, showing they are unsurpassed in purity, freshness, and taste, and are virtually contaminant free".

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