Chemopreventive effect of curcumin in colon cancer

An animal study of male rats

From Cancer Research 1999, Vol 59, Iss3 pp597-601

Curcumin is both an antioxidant and anti-inflammatory and it can inhibit chemically induced cardinogenesis in the skin, forestomach and colon . Curcumin was also shown to increase apoptosis (cell death), it inhibited growth of tumors in the colon.

This has not been studied in humans to any degree but animal studies are indicative.

Ann's NOTE: As a cancer patient, I resent the fact that wherever trials are conducted, money is being spent on pharmaceuticals and human trials while there is SO much resistance to studying natural substances in humans. Sometimes I think there is a kind of prejudice or resistance to non-toxic substances. It seems to me that researchers have 'forgotten' that a substance does not have to be toxic to be effective.

Curcumin is also known as the spice turmeric. It is present in Indian food cooking.


Oral Curcuma and Colorectal Cancer Patients

Clin Cancer Res, July 2001

Pharmacodynamic Action & Colonic Levels Curcumin
Pharmacology of Curcumin
Curcumin enhances effects: 5-fluorouracil and oxaliplatin
Denver Naturopathic News: Curcumin & Chemo

12/03 WARNING on certain CHEMOS

Effects of Dietary Curcumin on Glutathione S-Transferase (rats)

Clin Cancer Res, May, 2001

Induction of Glutathione S-Transferase Activity By Curcumin (mice)
Mechanisms of Anticarcinogenic Properties of Curcumin

Int J Biochem Cell Biol 1998

Herbal Flavonoids Reduce Colon Ca Risk (Rats)
Turmeric for Breast Cancer Protection

Dr. D'Adamo Speaks

Curcumin: Suppressive Effects on Human Bca cells

Intl J Cancer, 2002

Curry and TRAIL Fight Cancer

AACR meeting, 4/02

Dietary Curcumin Inhibits Chemo in Vitro

Cancer Res, 7/02

Turmeric/Curcumin/Curry and Radiation

American Society for Therapeutic Radiology and Oncology, 10/02

Protection for Radiation Therapy
Turmeric and Radiation Therapy
Turmeric & Blood Cancer

MD Anderson Cancer Ctr, 3/03

Curcumin & Irreversible Growth Inhibition/Apoptosis:Melanoma

AACR Abstract #R2722, 2003

Natural Cyclo-Oxhgenase-2 Inhibitors

Aliment Pharmacol Ther, 1/04

Curcumin Inhibits Growth Head/Neck Squamous Cell Ca

Intl J Cancer, 9/04

Curcumin Suppresses Growth of Head/Neck CA Cells
Turmeric as Treatment for Cystic Fibrosis

"Findings", October, 2004 issue National Institute of General Medical Sciences, NIH

Curcumin Blocks Melanoma Growth - In Vitro (Non-toxic)

Cancer, 8/05

Isoimperatorin (from Poncirus trifoliata Raf) Anticancer

Carcinogenesis, published online July, 2006

Curcumin: Natural Therapy for Cancer (in Cell Death Processes)

eCAM, Advance Access, 4/07 Oxford Journals

Curcumin & Oxidative Stress (In Cell Death Processes)
Curcumin and Cell Death
Curcumin and the Nervous System
Curcumin and Aging
Conclusions: Curcumin
Phase II Trial Curcumin - Patients w/Advanced Pancreatic Ca

Clin Cancer Res, 2008

Proteasome Inhibition could be 1 Mechanisms 4 Curcumin

Cancer Res, September 2008


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