Ctr for Advancement in Cancer Educ

Center for Advancement in Cancer Education (CACE) November 4, 2001 Philadelphia, PA

CACE offers advice and lots of excellent support/information for cancer patients interested in CAM. When you become a member, you get one year of free advice. Contact them for more information.

Wendy Trocchio, MS, RN, AOCN

Ms. Trocchio is an oncology nurse who became interested in CAM. She spoke to the audience from the perspective of a provider. She said that "people crave the caring touch" which Western medicine has forgotten.

Since consumers see CAM as out of their doctor’s area of expertise, she finds less consumer interest in integrated medicine. She suggests it is time to "shift the focus to consciousness and healing from disease management".

She is a strong believer in the mind/body connection. Together with a group of nurses, she has established Cancer Consciousness, a division of U.S. BioStrategies, Inc. offering nurse consultants who "will critically evaluate every available option in complementary, alternative, and traditional medicine, and help you design a care plan specific to your cancer and your personal goals".

This group can be reached at www.cancerconsciousness.com. They have a monthly newsletter called HOPEFUL that provides relevant and useful information on the latest therapies, as well as cutting-edge commentaries on cancer.

Loran Swenson, BioPulse Clinic

Originally Dr.Heberto Schramm, MD, Director of Research, Baja Research Center, Tijuana, Mexico was scheduled to make the presentation on IHT. (Dr. Schramm was unable to fly). Thus the presentation was not as scientifically oriented as it might have been.

Induced Hypoglycemic Treatment (Insulin-induced hypo therapy) was invented in 1927 by Dr. Manfred U. Sakel. It was first used among patients with schizophrenia or manic/depressives. It was found that people treated with this method had less cancer, and so it was proposed as a cancer therapy.

Wayne Martin, a lay cancer researcher suggested that BioPulse try this therapy. BioPulse generally sees patients who have been told there is no further conventional therapy available to them. Thus the clinic felt it was ethical to try this method.

Six people formed the first group who received the protocol. For the first 5 days, they tested appropriate doses for each person. On the 6th day, they administered the therapy which places the patient in a coma state. The clinic examined arterial blood every 15 minutes with an instant blood test that checks glucose levels. Blood glucose is brought down to 22 with the therapy. The treatment is usually given for five weeks (but can last as long as 12). A nurse stands by for every two patients. There is one doctor per 6 nurses.

Their first patient reported that most of her pain was gone (from bone mets).

Ann’s NOTE: As we have often noted, the first patient to try a new therapy seems to benefit mightily. Talk about your mind/body connection!

We were shown (what looked like bone) scans from two or three patients. Each seemed to have benefited somewhat in terms of reduction of ‘hot?spots.

Mr. Swenson stated that they have seen results with breast, prostate, colon and uterine patients and limited success with multiple myeloma. If a person has 50% involvment of organs,they will not use the therapy.

This clinic does not use chemotherapy with IHT although the treatment done in the U.S.- IPT - does (Chicago). Dr. Edelson in Atlanta also does a version.

Biopulse believes there is a potential for this therapy to be successful. About 176 patients in the last three years, have gone through the treatment with "no serious?problems, no seizures nor cardiac arrests. They have seen no long-lasting negative effects. Diabetics cannot take the treatment. The ‘response?rate is 100%, including both complete and partial.

From what Mr. Swenson told the audience, it sounded like about 15% survival but it is really difficult to make any judgments about the therapy without much more information. They do not seem to keep good records which is really WRONG. Much more documentation will be needed to demonstrate that this difficult therapy is really helpful.

The cost is about $800 per day which includes the hospital/clinic stay. It is possible that Blue Cross/Blue Shield may cover the costs. It may be necessary to return in 9-10 months.

The January 2000 Alternative Medicine magazine had an article about the therapy, calling it a "significant new treatment …amazing success in treating even end-stage cancer". The article talks about several patients: John Franzoni recently died of pneumonia (lung cancer patient) but no cancer was found in his body after death. Pamela Kenyon died of a bleeding ulcer.

Talia Yampel, a 13-year-old was the 13 person to go through the therapy. For the first three weeks on the therapy she showed no improvement. Then it was discovered that she had the habit of eating sugar directly from the packet each day, when this was stopped, she became completely pain-free. But there was no change in her tumor. When surgery was done in her native Israel, it was found through pathology, that the tumor no longer had malignant cells.

At the time of this article, only "thirty-odd cases (had been) treated over a four-month period", now it is over 175. They will not be able to 'prove' the value of this therapy without excellent record keeping. Obviously they cannot compare its success with any other therapy directly, but it would be useful for us to know the exact status of the patients, and to chart their results.

The BioPulse clinic also offers Ultra-violet blood illumination, hyperbaric oxygen chambers, live blood cell analysis, colon cleansing, chelation, dendritic cell therapy (more on this later in the report) and other options.

Isaac Cohen, LAc, OMD

Chinese Herbs in the Treatment of Breast Cancer: Clinical Findings and Case Report

Cohen started by discussing current survival stats for breast cancer. Stage I=83% (after 5 years), Stage II=74%, Stage III=57% and Stage IV=27%. At the 5-7 year mark, there are many local recurrences.

UC San Francisco (UCSF) Medical Center gathered ideas from clinical experience (historical use and safety information came from patients affidavits). They began testing individual Chinese herbs. 71 were examined, of which 69 were biological and 2 zoological.

They used these herbs with 4 human breast cancer cell lines and one mouse cell line. (Some of these were ER+ and some were ER-). They tried an anti-proliferative assay and found high activity and dose response (the more they give, the more ‘cell kill?. Chinese herbs have "been in use for the treatment of cancer since the Zhou dynasty (1100-400 B.C.) The literary record and continuous practice of herbal medicine provide a long-tested model of care that "opens possibilities for investigation".

Over 20% of the herbs had significant growth inhibition on most or all of the cell lines tested. The herbs were also tested on lung, prostate, pancreatic and lymphoma cancer cells.

Cohen said that the FDA is "amenable to the use of historical data and patient affidavits)".

UCSF has been conducting a variety of trials with Chinese herbs, Tibetan herbs and more.

Ann’s NOTE: There is lots more information about UCSF’s program in other sections (see Clinical trials area or Relevant Studies-SEARCH on Tripathy (name of doctor who heads breast cancer programs there).

Joel M. Evans, MD, Founder and Director, The Center for Women’s Health

Dr. Evans discussed the cancers that are thought to be related to foods:

Stomach - salt; Colon -fried foods, fats; Rectum - fried foods, fats, ETOH; Pancreatic - fried foods, fats; Breast - fried foods, fats; Uterus - obesity, fats; Ovary - fats; Prostate - fried foods, fats; and Liver - mycotoxins

Colon cancer is thought to be the most modifiable by diet of all cancers. Increasing physical activity, using folic acid containing multi-vitamin supplements, not smoking, reduced alcohol use, and reduced red meat intake are all identified with reduction in incidence.

Reducing animal fats and eating more healthy fats, i.e. Omega 3 essential fatty acids (flax, fish, walnut), cooking with olive oil, and adding more fruits and vegetables are all indicated to reduce cancer risks. The most dangerous fats are the trans-fats or hydrogenated oils (AVOID).

Dr. Evans told the audience that less than 10% of Americans actually eat 5 servings of fruits and vegetables a day. 40% have no fruit or fruit juice, 50% have no garden vegetable, 70% have no fruit/vegetable rich in Vit C, and 80% have no fruit/vegetable rich in caretinoids (source: Second National Health and Nutrition Examination Survey).

Sadly the top three American vegetables are French Fries (25% of all vegetables consumed in the U.S.), Iceberg Lettuce (99% water), and Catsup (Krebs-Smith et al, Arch Pediatr Adolesc Med, 1996 Jan;150(1):81)

As most of us know, fruits and vegetables contain vitamins, minerals, anti-oxidants, fiber and complex carbohydrates and phytochemicals, (all necessary for good health).

Organic produce was recommended as pesticide-free, and with more vitamins and minerals than sprayed produce. Organic meat and chicken (usually called free range) is hormone-free and antibiotic-free. A chart in Dr. Evans?handout shows that a ‘wild animal?has 36 calories of fat per 100 grams of beef, while a domestic animal has 225. Organic dairy is hormone and antibiotic-free.

Dr. Evans spoke about the dangers of white sugar suggesting that there was clear evidence in the body of its negative effects. Cancer cells need glucose for energy and survival. PET scans have shown that areas of tumor growth in the body have increased use of radioactive injected glucose. Sugar ingestion leads to insulin release. The more sugar eaten, the higher the levels of insulin in the body. High levels of insulin and IGF may be causative for cancers of the breast, colon, prostate, endometrium and pancreas.

Lifestyles associated with higher NK cell (‘killer cells? activity per Dr. Evans:

Diet rich in fruits and vegetables, regular meals, maintenance of proper body weight/composition, 6-8 hours of sleep per night, regular exercise, NO SMOKING.

Twelve Most Contaminated Foods (Source: Crinnion Alt Med Review, 2000;5(5):432

Apples, Apricots, Bell Peppers, Celery, Cherries, Chilean Grapes, Cucumbers, Mexican Cantaloupe, Green Beans Peaches, Spinach, Strawberries.

Dr. Evans discussed the value of Omega 3 Essential fatty acids in our diets. Omega 3’s are found in cold water fish (salmon, tuna, mackerels, sardines), and flaxseeds. Omega 6’s are found in nuts, seeds and grains.

A 1999 National Institutes of Health Workshop recommended the following amounts:

4-6 grams of Omega 6 daily and 2-3 grams of Omega 3 daily (Simopoulos et al, Prostaglandins Leukot Essent Fatty Acids 2000, 63(3):119.

"Essential fatty acids are thought to fight cancer by: inhibit(ion of) cellular signals that cause cancer cells to proliferate; protect(ing) cell membranes from trauma; inhibit(ing) the effects of inflammatory chemicals that fuel tumor growth; increas(ing) the production of 2-hydroxyestrone, an anti-tumor breakdown product of estrogen. (Goodman, The Omega Solution)."

High Omega 3 to Omega 6 ratios are linked to lower rates of (breast) cancer (Simonsen et al, Am J Epid 1998;147:342)

Dr. Evans talked about the Mediterranean Diet-high in fruits and vegetables, fish, olive oil, low in red meat. His slide showed the "projected decrease in cancer incidence if Americans shifted to the Mediterranean Diet:

25% decrease in colorectal cancer, 15% decrease in breast cancer, 10% decrease in prostate, endometrial and pancreatic cancer. (Trichopoulou et al, Cancer Epidemiol Biomarkers Prev, 2000 Spt9(9)869.

Next he spoke about the value of cruciferous vegetables in promoting Phase II detoxification which "cleanses the body of lipid soluble toxins and steroid hormones"; contain calcium d-glucorate which "promotes glucoronidation which is the most important phase II detoxification pathway"; contain isothiocyantes "which may induce Phase II enzymes".

Indole 3-carbinol (I3C)causes the body to metabolize estrogen in a beneficial way and is found in cruciferous vegetables. I3C is also found in soy and lignans (flax).

These vegetables include cabbage, kale, broccoli, Brussel sprouts, cauliflower, and watercress.

Here is what Dr. Evans had to say about soy:

"Soy is a legume that is so nutritionally complete it sustained Eastern populations through drought and famine. (It is) composed of protein, fat, carbohydrates, phytonutrients, fiber and isoflavones."

"Researchers at the University of Texas found increased urinary levels of 2-OH (protective form of estrone) but not 16-OH (negative form) in premenopausal women consuming a diet high in soy isoflavones (100-200 mgs/d). This shows that soy isoflavones increase the breakdown of estrogen into the anti-tumor 2-OH estrone pathway, and suggests that soy consumption, along with Indole 3-carbinol supplementation, may reduce breast cancer risk". (Lu et al, Cancer Res. 2000;60:1299).

Some soy negatives from Dr. Evans: "May be difficult for some (few) people to digest due to trypsin inhibitors, which block protein digestion causing gas and bloating. Contain phytates which decrease absorption of Ca, Mg, Fe, Zn. Not significant if part of a balanced diet. Decreased in miso and tempeh. Can inhibit thyroid hormone synthesis in some if eaten in large amounts (. 200 mg isoflavone/day). There is not one study in a peer reviewed journal showing an increased rate of breast cancer associated with soy consumption."

Dr. Evans suggests "It is preferable to get soy isoflavones from soy foods rather than supplements. Limit daily intake of soy isoflavones to 50-100 mg/day in a breast cancer prevention diet for premenopausal women and 50 mg daily in post-menopausal women or women with breast cancer."

Dr. Evans suggested that women get tested to find out their EFA composition, 2-OH:16-OH ratios, insulin and IGF levels and suggested Great Smokies Diagnostics as a good lab to use. www.gsdl.com Of course this lab offers many tests for both men and women.

Loran Swenson of the BioPulse clinic spoken about dendritic cell vaccines.

(One of the handouts was a chat transcript from WebMD, Dr. Keith Black, a neurosurgeon describing dendritic cell vaccines for prevention of brain tumors). Here is some information from that:

"Dendritic cells are antigen presenting cells and they are the most efficient cells that can present foreign antigens tot he immune system. They make up a component of white blood cells, represent 0.14 % of white blood cells, and are essential in the formation of an immune response".

The concept is that these vaccines will make cancer cells more ‘visible?to the patient’s immune system and harness our natural ability to ‘kill?cancer cells.

At the BioPulse clinic they use an 8-day process to prepare a vaccine from the patient’s own body. Then it is inserted back into the patient to "teach" the immune system to recognize cancer.

This same process is being used in the U.S at various institutes including Cedars Sinai Medical Center in Los Angeles where Dr. Black works. Dr. Black stated that although he could not provide specific results, they were encouraging in the small sample of patients they have given this vaccine to (significant improvement and survival).

The final speaker was Greg Anderson Founder and CEO of Cancer Recovery Foundation of America. His was a motivational talk.

He suggested that patients "create a state of body/mind/spirit/wellness and live from that state". Mr. Anderson was given 30 days to live back in December 1984 but has been cancer-free since 1989.

Some of his suggestions include: "When in doubt, eat a plant". "Exercise". "Put ‘toxic?relationships on hold". "Survivors tend to feel a sense of mission, purpose-my life counts". He also felt that it was important to forgive, connect, love and act.

The CACE website can be found at: www.beatcancer.org

They offer support and guidance for cancer patients and their families. They also have an extensive collection of books available for sale. "Combining the body’s natural healing potential with advances in medical science".

This meeting is held annually with diverse speakers. Reported by Ann Fonfa

Human Dendritic Cells & Tumor Apoptosis

Int J Cancer, 11/02

Dendritic Cell-based Vaccines in Breast/Gyn Ca
Retinoids Promote Moncyte Differentiation to Dendritic Cells
Inhibition of Liver Tumors by Dendritic Cell Inoculation
Clinical Response: Glioblastoma Multiforme w/Dendritic Vaccine

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