COX-2 Expression in Ova & Endo Ca

Expression of cyclooxygenase-2 in cervical, endometrial, and ovarian malignancies.

Landen CN Jr, Mathur SP, Richardson MS, Creasman WT.

Department of Obstetrics and Gynecology, Medical University of South Carolina, 96 Jonathan Lucas Boulevard, 634 CSB, Charleston, SC 29425, USA.

STUDY DESIGN: Semiquantitative immunofluorescent assays for COX-2 were performed on sections of cervical squamous cell carcinoma (n = 12), endometrial adenocarcinoma (n = 13), and ovarian serous adenocarcinoma (n = 9).

Levels of immunofluorescence for each sample were objectively measured, categorized as high, moderate, or negative expression and compared with normal cervical (n = 14), endometrial (n = 15), and ovarian (n = 13) tissue with the Fisher exact test.

RESULTS: Normal cervical tissue expressed COX-2 more frequently than cervical cancer (50% vs 23%), but the difference was not significant (P =.247). COX-2 was rarely present in normal endometrium (7%) and normal ovarian epithelium (0%) and was usually present in endometrial adenocarcinoma (69%, P <.001) and ovarian serous cystadenocarcinoma (89%, P <.001).

CONCLUSION: In this cohort, COX-2 expression is significantly more common in endometrial adenocarcinoma and ovarian serous cystadenocarcinoma, but not in cervical squamous carcinoma, compared with normal tissue.

Am J Obstet Gynecol. 2003 May;188(5):1174-6.

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