Clonal Chromosomal Alterations in Fibroadenomas

Original article

Clonal chromosomal alterations in fibroadenomas of the breast

Luciane Regina Cavalli a, Déborah Afonso Cornélio a, Lismeri Wuicik a, Ana Teresa Schmid Bras a, Enilze M.S.F. Ribeiro a, Rubens Silveira Lima c, Cícero Andrade Urban c, Silvia Regina Rogatto b and Iglenir João Cavalli a * cavalli@bio.ufpr.br

a Departamento de Genética, Universidade Federal do Paraná, Caixa Postal 19071, CEP 81531-970, Curitiba, Paraná, Brazil b Departamento de Genética, IB-UNESP-Botucatu, SP, Brazil c Departamento de Oncologia do Hospital Nossa Senhora das Graças, Curitiba, Paraná, Brazil

Abstract

A cytogenetic study on short-term cell cultures from 10 fibroadenomas of the breast is reported. Clonal chromosomal alterations were observed in all cases analyzed, involving preferentially chromosomes X, 12, 14, 20, and 22. Normal karyotypes were found in 34.9% of the cells.

The present findings are discussed together with the reports on fibroadenomas and other benign lesions of the breast described in the literature.

Although no specific chromosome abnormality to date can be attributed to a particular type of benign breast pathology, some recurrent alterations are starting to emerge and may characterize these benign breast lesions, differentiating them from their malignant counterparts.

Cancer Genetics and Cytogenetics, Vol. 131 (2) (2001) pp. 120-124 © 2001 Elsevier Science Inc. All rights reserved. PII: S0165-4608(01)00502-7

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