Chemotherapy Used Too Often

At End of Life

Chemotherapy Used Too Often at End of Life [05/14/2001; Reuters Health]

SAN FRANCISCO (Reuters Health) - Chemotherapy is used in approximately one third of patients who have cancers that are not likely to respond to the treatment during the last 6 months of their life, according to results of a new study.

The finding ``strongly suggests overuse of chemotherapy at the end of life,'' lead author Dr. Ezekiel J. Emanuel told attendees here at the annual meeting of the American Society of Clinical Oncology (news - web sites). ``Many are concerned with the quality of end-of-life care and specifically that patients should not be overtreated with ineffective therapies that won't improve their quality of life,'' Emanuel told Reuters Health.

Chemotherapy can have a number of side effects, including nausea, vomiting, fatigue and hair loss. Emanuel, of the National Institutes of Health (news - web sites), and his team looked at the billing records of nearly 8,000 patients who died from cancer in the state of Massachusetts in 1996.

``What we found is that in the last year of life, 41% of patients received chemotherapy, 33% had chemotherapy in the last 6 months of life and 25% received chemotherapy in the last 3 months of life,'' he said.

ASCO talk presented by Dr. Ezekiel J. Emanuel, NCI, May 2001

Pre-treatment: Dietary Supplements/Cisplatin

#311 beta-carotene,retinoic acid, quercetin & genistein

Altered Nutritional/Inflammatory Status:Increased Toxicity Risk
Supplement w/Magnesium, Potassium: Cisplatin
Dietary Enhancement of Mitomycin C
Multivitamin/Vit E Helped: Breast Ca Chemo
Metab Abnormalities w/weight loss & Chemo/RTx Head/Neck
Pomegranate Extract & Acute Nephrotoxicity/Hepatotoxicity - Rats
Value of Anthracyclines Questioned

ABC News, December 2007 as presented at the San Antonio Breast Cancer Symposium

Oral Amino Acid Supplements & Cardiac Function
Adriamycin & Multiple Antioxidants Chinese Herbal Formula
Early Stage Colon Cancer/Chemo (Patient perspective)

Patient perspective from Jean about Fred's colon cancer experience

Prognostic Disclosure: Near End of Life

Annals of Internal Medicine, 7/01

Older Adults Receive Intensive Chemo at End of Life
Chemo at End of Life: When is Enough, Enough?
Protective effect of hawthorn extract:cyclophosphamide (Mice)

Environmental Toxicology and Pharmacology January 2008

Second & Next Chemo: What do we KNOW?

Annals of Oncology, 1/02

Optimal Duration of CMF-Treatment Failure/Overall Survival
Chemo-induced Toxicities Reviewed

Source: Bionumerik Pharmaceuticals 6/04

PK Analysis of 5-FU Predicts Life-threatening Toxicities
Warfarin (Coumadin ) & Some Chemotherapies CLASH
Hiccups: Adverse Reaction to Chemo
Unusual Complication: Herpes Simplex...
Severe Nail Changes From Docetaxel
Risk Factors: Chemo-associated Venous Thromboembolism
Hearing Loss: Cisplatin (Esp Every Two Weeks)
Anthracyclines: Children's Arteries Damaged
Serious Adverse Events GREATER Than Prior Reporting
'Side' Effects of Chemotherapeutic Agents
PERMANENT Hair Loss - Taxotere
Antioxidants in Cancer Therapy-Review of Literature

Alternative Medicine Reviews, 1999 and more articles, IMPORTANT stuff

Review: Antioxidants do NOT Interfere w/Chemo or RTx
Antioxidant Supplementation on Chemotherapeutic Efficacy:systematic review
Introduction and Conflicting Views
Antioxidant Supplementations in Men Reduces Incidence CA
Use of Antioxidants & Cytotoxic Treatments
Dietary Antioxidants & Chemotherapy
Antioxidants Resolve Rtx Adverse Effects
Review of Italian Studies on Veg/Fruit/Antioxidants
Multiple Antioxidants Improve Efficacy
Systemic Screening of Total Antioxidants in Dietary Plants
High Oxidation/Low Antioxidant Levels...
Herbs, Vitamins & Antioxidants w/Cancer Treatments:TCM
Garlic (Allium sativum) & Pharmacokinetics of Docetaxel
Article References
Molec targets of dietary agents 4 prvntn & thrpy of cancer.
High Doses Antioxidants Do NOT decrease Chemo Efficacy
Supplemental antioxidants during chemo &radiation therapy?
Lung Ca Chemo MORE Costly, No Diff in Survival


Oral Oncology Products

Oncology Issues, 2/02

Lower Dose Capecitabine Better in Mets BCa
Lancet: Comparison of Chemo for Colon Ca

Ralph Moss, Weekly #36 5/14/02

Less Cycles of CMF (adj chemo)

Br J Cancer, 6/02

Discussion: Adj Therapy Postmenopausal Women
Editorial:Adjno Chemo Postmeno Lymph-Node Neg
Sequential Docetaxel: No Benefit in Early Breast Cancer
Opening Line of this Paper tells a Sad Tale

Br J Cancer, 5/02 "Cancer Chemotherapy is Limited"

Cancer Medicine's Dark Corners

Written and submitted by Gregory D. Pawelski

Letter re Ethics/Conflicts of Interest Oncology
Carcinomatous Menigitis:Taxane Induced?

Oncology, 12/02

Acral Erythrodysesthesia Syndrome:Docetaxel
Acute Myeloid Leukemia:Doxi & RTx

J Clin Oncol, 4/03

Therapy-related Acute Promyelocytic Leukemia
Synergistic Effects: Grape Seed Extract & Doxorubicin
Circadian Timing of Cancer Chemotherapy


Taxanes in Adj Early Stage Bca

Breast Cancer Res Treat, 7/03

Excessive Tearing & Canalicular Blockage:Docetaxel

ASCO Abstract #45

Weekly Docetaxel Causes Eye Problems
Effects of Black Cohosh on Chemotherapies

AACR Abstract #2721, 2003

Vit E & Paclitaxel w/Various Cancers
Chemo for Brain Mets Based on Chemosensitivity of Tumor

Eur J Cancer, 10/03

Severe Hepatic Sinusoidal Obstruction W/ Oxaliplatin

Abstract # 3541 ASCO, 2004

Bowel Perforation & Fistula Formation W/Bevacizumab

Abstract # 3017 ASCO, 2004

Chemo-induced Diarrhea & Dosing Intensity

Abstract #6128 ASCO, 2004

PABA Enhances Conventional Cancer Therapies

Intl Conf on Molecular Targets & Cancer Therapies, 11/04

Heated Chemotherapy w/Surgery More Effective
High-dose Chemo and Cell Support

Bone Marrow Transplant, 6/06

Patient Perspective on High-dose Chemo
HER2 &  Response to Paclitaxel in Node-Positive Breast Cancer

New England Journal of Medicine, Oct, 2007

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