ABSTRACT: Changing Incidence of Lobular Carcinoma in situ of the
Li CI, Anderson BO, Daling JR, Moe RE.
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA. email@example.com
Estimating the incidence of lobular carcinoma in situ (LCIS)
of the breast is challenging because it lacks both clinical
and mammographic signs and is usually an incidental finding
in breast biopsies performed for other reasons. In general,
population-based studies are believed to provide the most
accurate measures, but few documenting changes in LCIS incidence
rates over time have been reported.
LCIS incidence rates among women with no prior history of in
situ or invasive breast carcinoma from 1978 to 1998 were obtained
from nine population-based cancer registries that participate
in the Surveillance, Epidemiology, and End Results (SEER)
Program. Linear trends were evaluated using negative binomial
Overall, LCIS incidence rates increased fourfold
(95% confidence interval, 2.9-5.6) over the study period.
Specifically, they rose from 0.90/100,000 person-years in 1978-80
to 2.83/100,000 person-years in 1987-89, but then increased
only modestly up to 1996-98 where the incidence rate was
However, among women 50-79 years
of age, LCIS incidence rates increased continuously over the
study's duration. In 1996-98, 50-59 year-olds had the highest
incidence rate (11.47/100,000 person-years) and experienced
the greatest absolute increase in incidence over the study
period (9.48/100,000 person-years).
LCIS incidence rates have
steadily increased from 1978 to 1998 only among postmenopausal
women. Further research is required to assess what factors are
contributing to these trends.
[09/05/2002; Breast Cancer Research and Treatment]
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