EDITORIAL: Cancer during Pregnancy
07/11/99; New England Journal of Medicine

MEDSCAPE Except from: 8th International Conference on Primary Therapy of Early Breast Cancer; March 12-15, 2003; St. Gallen, Switzerland

"It seems clear that women who develop breast cancer during pregnancy may present with a higher stage due to delay in diagnosis, but that once matched stage for stage with other women, they do no worse.[34]

In addition, it has been suggested that physicians should recommend that women do not become pregnant for several years after a diagnosis of breast cancer, but that following that interval, pregnancy may not affect their outcome.

Unfortunately, much of these data are anecdotal, as women who become pregnant following breast cancer are a highly select group and are not typically randomized to treatment."

34.Mouridsen HT, Kroman N. Pregnancy before and after breast cancer. Program and abstracts of the 8th International Conference on Primary Therapy of Early Breast Cancer; March 12-15, 2003; St. Gallen, Switzerland. Abstract S32.

Author:Kathleen I. Pritchard, MD, Professor, Department of Medicine, Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario, Canada



11/02 A recent study/survey of National Cancer Institute-designated cancer centers showed that 14% offer counseling on fertility and sexual issues.

EDITORIAL: Cancer during Pregnancy [07/11/99; New England Journal of Medicine]

Cancer is rare during pregnancy, occurring in only about 1 per 1000 live births. More than half the cases are tumors of the uterine cervix, breast, or thyroid, which can metastasize to the placenta but not the fetus. Melanoma and hematologic tumors, which also can invade the placenta, may cross into the fetal circulation. In a recent review, Baergen et al. described 19 cases of maternal melanoma that had metastasized to the placenta. In five of these cases the tumor extended into the fetus, which died of metastatic melanoma in four of the five cases. The transmission of maternal leukemia to the fetus has been documented by immunologic similarities between the leukemic cells in the mother and those in the fetus. The report in this issue of the Journal by Catlin et al. clearly shows that an aggressive lymphoma can enter the fetal circulation and affect the fetus. The authors point out that the mother in the case they studied was not homozygous for the male fetus's HLA haplotypes and the fetus was not immunocompromised, making it likely that the lymphoma, a highly aggressive tumor, grew without hindrance by the fetus's immature immunologic system.


Pregnancy & Overall Survival

J Clin Oncol, 3/01

Relation of Reproductive Factors to Mortality from Bca
Obstetricians Should Do Breast Exams
Mgment & Clinical Outcomes Pregnant Pts w/Inv Cervical Ca
Higher intake of protein from vegetable sources = lower risk ovulatory infertility

Am J Obstet Gynecol, 2008

Pregnancy & Radiation

Cancer Treatment Reviews March 2001

Vulnerable Women's Eggs
Irradiated Uterus & Pregnancy Issues
Pregnancy & Chemotherapy

J Human Reproduction, March 01, study of mice

Assessement of Fetal Risk Assoc w/Exposure to Chemo
Chemo May be Safe for Some Pregnant Women
Pregnancy Issues with Imatinib
Fertility Options Assessed

Journal Fertility/Sterility April, 2001

Short Burst Tam & Fertility
Oncologist and Sperm Banking Before Treatment
Information Needs for Younger Women
Evidence of Herb/Drug Interaction w/Contraceptives
Ovarian Tissue Frozen, Embryo Obtained Later
Preservation: Fertility in Young Women w/Cancer
Experimental Surgery: Cervical Trachelectomy
Female Infertility & Wirn Technique-Manual Phys Thrpy
Live Birth After Orthotopic Transplantation
Fertility, Gonadal & Sexual Function: AFTER Testicular Ca
Pregnancy Possible After Cervical Surgery
Risk of Late-stage After Childbirth

Am J of Epidemiology, June 2001

Breastfeeding & Reduced Risk of  Bca

Am J of Epidemiology, 6/01

Lifetime Lactation: Korean Women's Cohort
Breast-feeding & Risk Reduction BRCA1/BRCA2
Sue Walker's Story

LINK - Almost 8 months pregnant at diagnosis

Abortion

Int'l J of Cancer, May,2001

Abortion & BC-Review Finds Insufficient Data
Judge Dismisses Suit Attempting to Link Bca/Abortions
Bca/Abortion in Chinese Women (China)
Abortions/Bca:Records-based Case-Control Study
Abortion & Breast Cancer:NYTimes Editorial
Induced/Spontaneous Abortion & Bca Risk: None
Contraceptive methods, Induced Abortion & Colon Ca
Fertile Hope

LINK nonprofit organization dedicated to providing reproductive information, support and hope to cancer patients

Large-Core Needle Safe/Effective

American Roetgen Ray Society, 5/02

Mother Risk Org

LINK evidence-based information on safety/risk of drugs, chemicals & disease during pregnancy/lactation.

Female Childhood Cancer Survivors

Euro Soc for Human Reproduction & Embryology, 7/02

Pediatric CA & Subsequent Pregnancy
Increased Risk of Bca w/RTX-Hodgkin's & Pregnancy
Review:Pregnancy & Malignancy

The Oncologist, 8/02

Overview from Senologist
Recent Developments:Cancer/Pregnancy
Chemo-induced Amenorrhea/Fertility
Bca in Pregnancy:Literature Review
Lactation & Mammograms
Pregnancy SAFE for Cancer Survivors & Babies
Pregnancy, breast ca characteristics, receptor status
Imatinib Use During Pregnancy May Cause Serious Fetal Abnormalities
Hope for Two Pregnant with Cancer

LINK to organization for Pregnant Women with cancer

Nausea/Vomiting: Acupressure Wristbands

Obstetrical & Gynecological Survey, Janaury, 2001

Product to Help with Vaginal Dryness

SYLK

Help For Sexual Problems: Men & Partners

Psycho-Oncology, 6/03

Pilot Intervention: Enhance Sexual Rehab After Prostate Ca
Sexual Functioning after Testicular Cancer
Infertility After POMB/ACE Chemo/Rads

Brit J Cancer, 10/03

Ginger

Articles/studies

Zingiber officinale (GINGER) as Antiemetic
Ginger for Nausea/Vomiting (Pregnancy)
Element of Ginger Triggers Cell Death, Enhances Cisplatin
Ginger in prevention of nausea/vomiting after major GYN surgery
Different Gene Expression in Breast After Pregnancy

ASCO, 2004

Pregnancy Lower Back Pain & Acupuncture

Acta Obstetricia et Gynecologica Scandinavica, 3/04

Tamoxifen and Pregnancy

The Breast, 12/04

Young Moms with Breast Cancer

Article in Spring 2003 CBCRP newsletter

Various Pre-Cancerous Treatments & Pregnancy Problems

Lancet. February 2006


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