Experimental Blood Test Shows

Promise in Detection

An experimental test that detects a specific protein in blood samples appears to be promising as a screening test for breast cancer, the manufacturer, Matritech, Inc. of Newton, Massachusetts announced on Thursday.The test detects nuclear matrix protein (NMP), a protein that may be elevated in the blood of people with cancer. The test is approved in the US, Japan and Europe for bladder cancer screening, but not for other purposes. In a new study, the test was used in 78 women who had early or advanced breast cancer, a precancerous condition, or no cancer at all. The test correctly identified all cancer cases, and four out of five women with a precancerous condition known as ductal carcinoma in situ. ``We detected every case of cancer, and ruled out cancer for all normal samples,'' David L. Corbet, president and COO of Matritech, said. ``Based on this...we consider 'proof of concept' complete.''

However, due to the small number of specimens, which came from patients that the company knew did or did not have cancer ahead of time, Dr. Clifford Hudis, chief of breast cancer medicine services at Memorial Sloan-Kettering Cancer Center, expressed concerns that the test may not be accurate with larger patient populations. ``If (the test) has even a low rate of false-positive results...(and you test) a million people...then you have thousands, literally, of positive results that don't indicate cancer,'' he said in an interview with Reuters Health. False-positive results occur when a test signals the presence of a disease, but the patient does not in fact have the disease.

Thanks to Reuters Health (and BreastcancerNetwork)


Genes Assoc w/Types & Stages of Bca

Federation of Euro Cancer Soc., 3/02

Oncotype DX (TM) Breast Cancer Assay
MammaPrint Test (Agendia)

Hem/Onc News, posted here 4/07

Optical Biopsy Uses Light

3rd European Breast Cancer Conference, 3/02

Vitamin B12 Imaging for Breast Cancer Diagnosis

Mayo Clinic, posted here 4/07

NASA Probe Diagnoses Cancer in an Instant

NASA press release, 9/20/01

Blood Flow & Metabolism in LABC

J Nuclear Medicine, 4/02

Cancer Screening & The Individual

New York Times, Editorial Page, 4/14/02

Breath Test for Bca

The Breast Journal, 7/03

Associations of HPV & Breast Cancer

Breast Ca Res & Treat, 3/04

New Breast 'Pap' Smear

DukeMed News

Mammostrat

A Novel Molecular-Targeted Prognostic Immunohistochemistry Test for the Risk Profiling of ER+ Breast Cancer Patients

LINK: "Mammostrat is a five-antibody prognostic test for estrogen receptor-expressing, hormone receptor-treated (tamoxifen) breast cancer patients with node-negative disease".

Dr. Robert L. Bard's work with ultrasound/scans

LINK: "Acute trauma to the breast occurs in seat belt injuries producing hematomas that may result in permanent scars. Chronic trauma in the form of environmental toxins may predispose to breast cancer".

"The combined use of breast sonograms with Doppler blood flow study will provide early detection of most highly malignant cancers resulting in life saving early diagnosis and sparing the patient radical surgery. This result requires special training by the physician & state of the art sonograms".


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