Antiproliferative and apoptotic effects of selective
phenolic acids on T47D human breast cancer cells: potential mechanisms
Marilena Kampa, Vassilia-Ismini Alexaki, George Notas, Artemissia-Phoebe Nifli, Anastassia Nistikaki, Anastassia Hatzoglou, Efstathia Bakeogeorgou, Elean Kouimtzoglou, George Blekas, Dimitrios Boskou, Achille Gravanis and Elias Castanas
Corresponding author: Elias Castanas (email@example.com)
Introduction: The oncoprotective role of food-derived polyphenol
antioxidants has been described but the implicated mechanisms
are not yet clear.
In addition to polyphenols, phenolic
acids, found at high concentrations in a number of plants,
possess antioxidant action. The main phenolic acids found
in foods are derivatives of 4-hydroxybenzoic acid and
4- hydroxycinnamic acid.
Conclusions: Phenolic acids exert a direct antiproliferative
action, evident at low concentrations, comparable with those
found in biological fluids after ingestion of foods rich in
Furthermore, the direct interaction with the
aryl hydrocarbon receptor, the nitric oxide synthase inhibition
and their pro-apoptotic effect provide some insights into their
biological mode of action.
Breast Cancer Res,2004, 6:R63-R74
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