Anti-Cancer Agents from the Ocean/Coral Reefs

Array Of Marine Derived Anti-Cancer Agents Now In Trials

A number of experimental anticancer agents derived from marine sources are undergoing preclinical and clinical trials and there is no end in sight.

A group of scientists have formed a world-wide collaboration to investigate the anticancer effects of organisms found on coral reefs and in deep ocean thermal vents, according to Dr. Gilberto Schwartsmann and colleagues at Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.

Over the past few years, about 3,000 new compounds from various marine sources have been described.

"This activity has been largely due to improvements in the technologies involved in deep-sea sample collection and large-scale drug production through aquaculture and drug synthesis which took place in the 1980s," the clinicians point out. "These developments suggest that, in the future, the oceans will become an important source of novel chemical classes not found in the terrestrial environment."

The manipulation of microbial biosynthetic pathways through genetic engineering has also led to the production of interesting new molecules. "These living organisms represent a rich reservoir of genetic and metabolic diversity, which is ready to be exploited and which will certainly make anticancer drug discovery even more challenging in the next few years."

Thanks to Doctor's Guide 4/01

Marine Bacteria a Source of Anti-cancer Drug

Science Daily, 10/01 Applied and Environmental Microbiology

Producing Quantities of Anti-cancer Agent
Antioxidant & Hepatoprotective potential agaro-oligosaccharides in vitro/ in vivo

Nutr J, 12/06

Fucans from Seaweed Inhibits Invasion

Anticancer Res, 7-8,02

Nine different Fucoidans from brown seaweeds
Fucoidan-Vitamin C complex suppresses tumor invasion
Mining The World's Oceans for Medicinals

10/02 Meeting report

Salinosporamide A-Inhibits Cancer Growth
Discodermolide - (Marine Sponge) w/Paclitaxel (Taxol)

J Cancer Research, 7/04

Photochemoprvtn of UVB-induced skin crcingnss by brown algae polyphenols

Abstract #B77 Frontiers, 11/06

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