Report of American College for Advancement of Medicine meeting, May 16-18, 2003 Washington, D.C.
By Ann E. Fonfa
Dr. Jeffrey D. White, M.D., Director of Cancer Complementary and Alternative Medicine, National Cancer Institute (NCI-OCCAM), discussed a small randomized trial of vitamin E and cisplatin.
A human study of 47 patients randomized to vitamin E at 300 mg/d orally before cisplatin therapy and continued for 3 months after suspension of treatment.
Results: 27 patients completed 6 cycles of cisplatin, there were 13 in the vitamin E group and 14 in the control group. Neurotoxicity incidence was “considerably lower with vitamin E - 30.7% vs 85.7%; P<.01.” Neurotoxicity score: “significantly lower with vitamin E - (2 v 4.7, P<.01).”
Dr. White also indicated that they will continue to use PC-SPES with prostate cancer as soon as they have a source for uncontaminated product.
Steve Austin, N.D. of Portland, OR addressed the question of the use of antioxidants during chemotherapy treatments. He said that the current controversy and ‘belief’ system of a conflict, was based on a hypothetical article written by Livingston and Labriola. He indicated that Dr. David Lamson (Tahoma Clinic, Renton, OR, Coordinator of Oncology, Bastyr University), had written two articles from the opposite viewpoint, and that he himself had written one. Austin suggested that there has been no data demonstrating a conflict of usage.
Ann’s NOTE: In fact several Centers of the National Institute(s) of Health are cosponsoring a meeting on Antioxidants and Cancer, June 26-27, 2003. For more information, go to:http://www3.cancer.gov/prevention/frpca2003/
Also we offer the articles referred to above on antioxidants on our site: http://annieappleseedproject.org/anincanthero.html
An interesting talk by Todd Bezilla, D.O. discussed exercise as a way to improve libido in women. He suggested learning to control one’s breath first was of key importance. He stated that exercise in water will not improve bone density, although it is very good for other aspects of health. He suggested using Tai Chi, Yoga and other balance-oriented calisthenics 4-5 times a week (ten minutes per session). For weight training exercises, he suggested 15-20 minutes 3 times weekly. He did not believe going slowly (a current concept) would benefit and suggested it might raise blood pressure.
For flexibility issues (major joints, body regions and trouble areas), he suggested stretching after a workout, or after shower/sauna.
Ann’s NOTE: People with lymphedema or the potential to develop it (that’s all of us who have had [probably more than one] lymph nodes removed), need to avoid the heat of a sauna, though it has been suggested that infra-red saunas may be different. In response to my question, he did agree that varying the type of exercise done daily is most beneficial.
Dr. Bezilla mentioned the benefit of icing after a workout whether it hurts or not. He suggested this was particularly beneficial if you had an area that tended to be hurt.
Stanislaus Burzynski, M.D., Ph.D., Medical Director, Burzynski Research Institute, Burzynski Clinic and Pharmaceutical Plan, spoke about the 78 Phase II clinical trials on antineoplastons he is currently running under FDA supervision/approval. He reports weekly, monthly and annually on progress.
He showed a slide from the University of Kurume Medical School in Japan. The patients had colon cancer with liver metastases. All received chemo with 91% survival in those also receiving antineoplastons A10 and AS2-1 versus 39% in control group.
Studies at the above institution as well as the Medical College of Georgia and the Buryznski Institute “revealed that animals can be protected from development of breast, lung and liver cancers, by adding small amounts of Antineoplaston A10 to their food.
Preventive effects against cancer was found in animals exposed to common carcinogens, including benzo(a)pyrene, uretane and aflatoxin B1".
Dr. Burzynski stated that 1.4% of all patients show serious anemia, 1.5% have hypercalcemia and less than 1%, toxicities of skin. Positive effects include increased energy, improved healing, and reduction of cholesterol.
Kedar Prasad, Ph.D., Former president International Society for Nutrition and Cancer, Director for the Center for vitamins and Cancer Research, U Colorado Health Sciences Center.
The title of this talk was “Rationale for Using High Dose Multiple Antioxidants as an Adjunct to Standard or Experimental Cancer”.
Dr. Prasad stated that most objections to multiple antioxidant use with cancer therapies, hinge on the idea of free radicals and oxidation. If one believes that antioxidants only function as scavengers of free radicals, then the theory goes, they must also protect cancer cells.
He believes this is a wrong assumption. There is evidence that there is enhancement of the cancer therapy using vitamin A, retinoic acid, vitamin E succinate, vitamin C and beta-carotene. Dr. Prasad’s work indicates that antioxidants can also induce anti-angiogenesis.
He suggests that delivery before, (15-30 minutes), and every day during the entire treatment period would be appropriate. He pointed out that there have been NO papers written that show damage in any way for such a protocol.
Dr. Prasad said that dietary antioxidants at low doses before treatment would be a mistake. Before treatment antioxidants can even (beneficially) cause apoptosis without going through P53 or P16.
Once radiation therapy or a chemo like 5Fu are given, antioxidants do work through the tumor suppressors. Since antioxidants decrease the expression of c-myc and H-ras (oncogene), use before radiation therapy or concurrently is best.
He stated that the use of alpha lipoic acid, n-acetyl cysteine (NAC) or glutathione at any dose even just before treatment, would be a mistake. Glutathione makes cells resistant to, and causes them to act as though they were in s-phase. Glutathione by IV shows inhibition of cancer cells. But Dr. Prasad stressed that this is NOT compatible with chemotherapy or radiation therapy.
He stated that super oxide disumutase protects from radiation damage.
Vitamin E succinate causes growth inhibition, differentiation and apoptosis. Vitamin C at 200 ug/ml causes growth inhibition in some cells, as does beta-carotene at 20 ug/ml. Together they offer much better efforts.
BIG news: Vitamin E succinate can convert hormone ‘insensitive’ (ER negative) breast cancer to ER positive. It can also work in prostate cancer as it is hormone sensitive too.
Ann’s NOTE: Apparently there is also evidence that Vitamin A can act similarly. Ann had this effect occur as a result of treatment. See Ann’s Bio for more information. Clinicians and researchers have confirmed that this is so. In a SEARCH for studies, I found ‘throwaway’ type referrals to this phenomenon, as though it were so obvious, nothing really needed to be said. How can this be?
It is known that vitamin C in small doses can induce cell growth, thus taking a multi-vitamin (containing 60- 90 mg) such as some oncologists recommend, may be harmful. Too little C or other antioxidant is not good according to Dr. Prasad’s research.
Vitamin C taken at 100 ug/ml has a beneficial effect on its own, but combined with E, A, beta-carotene, it can achieve a 90% ‘kill’ rate.
Dr. Prasad made it clear he is speaking about d-alpha tocopherol (not synthetic dl). The antioxidant combination is okay with 5 FU and Adriamycin. A study by Chinery et al, Nature Medicine actually tested vitamin E with 5 FU, but the combination antioxidants are best. (Invest New Drugs 2001;19(1):21-7, A phase I study of vitamin E, 5-fluorouracil and leucovorin for advanced malignancies)
Tamoxifen & C & beta-carotene & retinoic acid & E succinate are an excellent combination.
Hyperthermia benefits from added vitamin E.
Dr. Prasad’s laboratory has been working on the best combination of vitamins in the best doses.
Hugh Riordan, M.D., President and Director of the Center for the Improvement of Human Functioning International, and the Bio-Communications Research Institute, spoke on “The Use of High Dose Intravenous Vitamin C in Cancer and Other Diseases - a 28 year Perspective”.
Dr. Riordan’s work is based on orthomolecular principles. In his many years of practice he and his associates have administered as much as 24 hour continuous IV vitamin C for one full month without damaging effects.
A normal dose for a person with cancer at their facility might be 200 grams administered over 5 hours. Dr. Riordan has been receiving such doses himself for years.
Dr. Riordan stated that in the United States about 39% of men and over 43% of women do not even receive 60 mg of vitamin C daily. Normal young males need about 200 mg as per the work of Mark Levine (NIH).
Achievable plasma levels of vitamin C are 100-fold greater with intravenous infusions than oral intake.
Dr. Riordan said that his group has found that administering lipoic acid increases the effectiveness of vitamin C. He stressed that this must be given only if the patient is NOT receiving chemotherapy or radiation.
From: AnnFonfa@aol.com [mailto:AnnFonfa@aol.com]
Sent: Sunday, June 01, 2003 6:41 PM
To: Prasad Kedar
Subject: I noticed something interesting
In looking over my notes from Dr. Hugh Riordan's presentation on the use of vitamin C, I saw that he stated that they used lipoic acid to enhance the tumor-killing effects of vitamin C. He also mentioned that this was in patients who did not/are not receiving chemo or radiation.
Do you feel this would be compatible to the statement you made about avoiding lipoic acid (and glutathione/ NAC) during treatment?
Thanks for a response.
You are correct. Alpha-lipoic acid should be avoided only during standard cancer therapy. Dr. Riordan’s strategy is to improve the degradation of vitamin C so that the plasma level of vitamin C persists for a longer time.
Isaac Eliza, M.D., M.S., Lac spoke about “Modified Citrus Pectin in the Prevention and Treatment of Cancer”. He is a formulator of dietary supplements, lectures on Traditional Chinese Medicine and integrative medical approaches and holds patents for several of his unique herbal formulations.
Modified Citrus Pectin is a complex polysaccharide (long chain carbohydrate) obtained from the peel and pulp of citrus fruits such as lemons, grapefruits, oranges and tangerines. This long chain of sugars has numerous branches with important binding capabilities that are related to pectin’s unique antimetastatic attributes.
In vitro and in vivo research on modified citrus pectin (MCP) “demonstrated its ability to interfere with cell-cell interactions preventing adhesion of prostate cancer cells to endothelial cells, thereby reducing metastasis potential. Interactions between the galacroside-binding molecules,(galectins) on the surface of tumor cells and MCP were the purported mechanism of action. Subsequently, the importance of galectin molecules over-expression on cancer cells for primary tumor growth, angiogenesis, and metastasis has been elucidated.
It is not surprising that more recent research has expanded the anti-cancer properties of MCP to include anti-angiogenesis, inhibition of primary tumors, as well as prevention of metastasis in human breast and colon cancer in a murine (mouse) model. (Nangia-Makker, P et al, JNCI 2002;94(24):1854-62)
Clinical studies, a phase one pilot trial and subsequent phase two trial have validated the effectiveness of MCP in the treatment of prostate cancer.”
In a phase II study, twelve patients were given 15 grams of MCP (PectaSol, EcoNugenics, Inc. Santa Rosa, CA 95407) per day for one year. Six out of the twelve subjects more than doubled their PSA doubling time. Two other human subjects experienced a decrease in their absolute PSA values. (Guess B, et al, The Prostate 2003;54(2):88-94
Dr. Eliaz notes that the MCP he is referring to throughout this article has the following characteristics: molecular weight between 10,000 and 20,000 daltons, DE <10% (degree of esterification), sugar content matters too. For more information on this product see Clin Prac of Alt Med, Volume 2, No. 3, Fall 2001:177-179.
MCP is well tolerated. Although, based on the human clinical trial and our clinical experience, the optimal dosage for slowing of metastasis may be 15 grams per day, divided into three doses. “It is recommended to use MCP for one year after your successful treatment” (referring to surgery or radiation for prostate cancer”. Dr. Eliaz also suggests that taking 15 g per day for a few weeks after a surgical biopsy or surgery, will “help prevent cancer cells from spreading”. Dosages as low as 3 to 5 g per day can be beneficial as a preventive measure. Take this product on an empty stomach, preferable 1-2 hours away from other supplements.
Two hours is considered enough time to have an empty stomach in between meals.
Dr. Eliaz also suggested people with cancer take medicinal mushrooms which “have been well researched for their anti-tumor and immune stimulating effects”. He suggests a ‘priming’ dose for one to two months. This dose is two or three times the maintenance level. Then drop to the normal maintenance dose which is typically the suggested dose. He suggest doubling the maintenance dose during the first two weeks of spring and autumn.
Dr. Eliaz noted that it is important to take medicinal mushrooms on a long term basis as some benefits “require and extended time of consumption”. He also suggested using many different varieties including (for serious health issues): Coriolus, Cordyceps, Reishi, Polyporus, Maitake, and Agaricus. For prevention of common and serious illness: Shitake, Hericum, Auricularis, Poria, Tremella, Coriolus, Cordyceps, Resishi, Polyporus and Maitake.
He also suggested the use of Thymic Protein A as a high normal dose for three days and low normal dose for one month. Then reduce to intermittent use (low normal dose 2-3 days per week).
Ann’s NOTE: Back in 1995 when I experienced the first of many local recurrences, I began using MCP. Unfortunately I have no way of knowing if this product made a difference in my health. As of June, 2003 I have not developed metastatic disease. There is no connection that I can show. Clearly it would be wonderful to have randomized multicenter trials of high risk cancer patients. We need such studies so that we can have more access (and insurance coverage) of ‘natural’ substances that may help us.
Here is the results of a query to Dr. Eliaz:
Thanks for the E-Mail. MCP can be taken on a long term basis. For prevention, I recommend 5 grams per day. For patients with active disease, 15 grams per day. Post treatment, I recommend the full dosage for 3-5 years, depending on the condition and the type of cancer followed by a 5-10 grams per day thereafter.
We are seeing encouraging preliminary results with MCP as a chelating agent. For chelation purposes, subjects are using 15 grams per day for one month (with no heavy load of heavy metals) and for a longer period of time if there is a documented heavy metal load. I think that at the end, MCP at 3-5 grams per day should be a part of a daily regimen for all of us.
Patrick Quillin, Ph.D., Director of Nutrition for Cancer Treatment Centers of America for the past ten years, spoke on “Nutrition Therapies to Improve Outcomes in Cancer Patients: Focus on Sugar and Fats”.
Dr. Quillin is the author of “Beating Cancer with Nutrition” and has a website www.nutritioncancer.com where I found the following topics:
1) Nutrients make chemo and radiation more toxic to the cancer and less damaging to the patient.
2) Starving the cancer by controlling blood glucose through diet and supplements.
3) Common vegetables, herbs, and seasonings that have powerful anti-cancer activity.
4) Malnutrition kills more than 40% of cancer patients.
5) Turbo-Charging your immune system to find and destroy cancer cells in your body.
6) Sugar feeds cancer.
7) Nutrients can slow and reverse cancer growth. Learn about commonly available and inexpensive vitamins, minerals, herbs, glandulars, fatty acids, food extracts, and probiotics to fortify your body against cancer.
Quillin offered this look at a ‘healthy meal plate’ - 1/3 cooked plant food (oatmeal, beans, bread, tortilla, pasta, yams, grains, nuts, legumes, cooked vegetables)
1/3 lean protein source (fish, wild game, poultry, lean beef, eggs, brewers yeast, beans, dairy, spirulina, kelp)
1/3 raw fruits and vegetables (tomato, spinach, carrots, peppers, fruit, broccoli, cabbage, onion, etc.)
This conference had many other speakers and lots of terrific information. Tapes are available by contacting acam.org
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