Alcohol, Wine & Risk of Ova Ca

#A172 Alcohol, Wine, and Risk of Ovarian Cancer.

Penelope M. Webb,1 David M. Purdie,1 Christopher J. Bain,2 Ad®®le C. Green.1

Queensland Institute of Medical Research,1 Brisbane, Qld, Australia, University of Queensland,2 Brisbane, Queensland, Australia.

Background: Moderate alcohol intake can influence sex hormone levels and affect ovarian function as well as increasing breast cancer risk.

This suggests that alcohol consumption might also influence ovarian cancer risk.

Methods: We have evaluated the association between alcohol consumption and risk of ovarian cancer among 696 Australian women with histologically-confirmed epithelial ovarian cancer and 786 cancer-free control women, selected at random from the electoral roll.

Sociodemographic information and a detailed reproductive history were collected in a face-to-face interview and information about diet and alcohol consumption was obtained from a food frequency questionnaire.

Logistic regression was used to calculate odds-ratios (OR) and 95% confidence intervals (95%CI) adjusted for potential confounders. We have also brought together all of the published data evaluating the association between alcohol consumption and epithelial ovarian cancer to comprehensively examine this association.

RESULTS: Overall, 59% of women drank less than one standard drink per week and only 5% of cases and 8% of controls drank an average of two or more standard drinks per day. Compared to non-drinkers, the OR for women who drank an average of two or more standard drinks per day was 0.49 (95%CI 0.30-0.81).

This effect did not differ between invasive and borderline cancers and did not vary for the different histological subtypes of ovarian cancer.

The inverse association was, however, restricted to wine (OR=0.56, 95%CI 0.33-0.93 for °›1 glass/day vs non-drinkers) with no effect seen for beer (OR=1.26; 0.65-2.46) or sherry/spirits (OR=1.07; 0.59-1.95).

Combining our results with the six previous population-based studies gave a pooled OR of 0.72 (95%CI 0.54-0.97) for the highest alcohol intake group versus non-drinkers.

Conclusions: These data suggest that alcohol does not increase risk of ovarian cancer; rather, the population-based studies conducted to date suggest that alcohol consumption is associated with a reduced risk of ovarian cancer.

In our Australian study population, this inverse association was due solely to wine consumption suggesting it might be a consequence of anti-oxidants and/or phytoestrogens found in wine rather than alcohol itself.

Frontiers in Cancer Prevention Research, 2003 AACR

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