In this section we have articles about YOUNG Women and Older Women. It is amazing that both groups seem to be missing from most evidence-based studies.
ABSTRACT: What is the evidence for a reduced risk of local recurrence
with age among older patients treated by breast conserving therapy? [02/01/2002; The Breast]
With the rising age of the population and the proposed extension
of the breast screening programme to older women, increasing
numbers of older patients are becoming eligible for breast conserving
surgery and post-operative breast irradiation. Women over the
age of 70 have traditionally been omitted from randomized controlled
trials for assessing the role of breast radiotherapy after local
surgery. The majority of trials suggest that local recurrence
rates do decline with age.
Similar conclusions are suggested
by many non-randomized studies. Comparison of randomized and
non-randomized studies is limited by differing extent of classifying
tumour margins, nodal status, use of adjuvant systemic therapy,
sample size, analytical approaches and duration of follow-up.
Large randomized trials in older women are needed to assess whether,
with careful attention to obtaining clear tumour margins, radiotherapy
is required in low risk, ER positive, node negative breast cancer
patients following wide excision and adjuvant tamoxifen.
both randomized and non-randomized studies, only a few studies
have failed to demonstrate an impact of age on recurrence rates
following breast conserving treatment, with the majority finding
a reduction in local recurrence rates with increasing age.
for interpretation, no studies suggest that recurrence rates
increase with age.
The variation in analytical approaches and
sample sizes are such that the variety of conclusions is not
The results are compatible with a tendency for local
recurrence rates to fall with age, but the variability is such
that one cannot quantify this change with any precision.