Age & Evidence of 

Local Recurrence

In this section we have articles about YOUNG Women and Older Women. It is amazing that both groups seem to be missing from most evidence-based studies.

ABSTRACT: What is the evidence for a reduced risk of local recurrence with age among older patients treated by breast conserving therapy? [02/01/2002; The Breast]

With the rising age of the population and the proposed extension of the breast screening programme to older women, increasing numbers of older patients are becoming eligible for breast conserving surgery and post-operative breast irradiation. Women over the age of 70 have traditionally been omitted from randomized controlled trials for assessing the role of breast radiotherapy after local surgery. The majority of trials suggest that local recurrence rates do decline with age.

Similar conclusions are suggested by many non-randomized studies. Comparison of randomized and non-randomized studies is limited by differing extent of classifying tumour margins, nodal status, use of adjuvant systemic therapy, sample size, analytical approaches and duration of follow-up. Large randomized trials in older women are needed to assess whether, with careful attention to obtaining clear tumour margins, radiotherapy is required in low risk, ER positive, node negative breast cancer patients following wide excision and adjuvant tamoxifen.

Within both randomized and non-randomized studies, only a few studies have failed to demonstrate an impact of age on recurrence rates following breast conserving treatment, with the majority finding a reduction in local recurrence rates with increasing age.

Importantly for interpretation, no studies suggest that recurrence rates increase with age.

The variation in analytical approaches and sample sizes are such that the variety of conclusions is not surprising.

The results are compatible with a tendency for local recurrence rates to fall with age, but the variability is such that one cannot quantify this change with any precision.

<35 Years Old with Operable Breast Cancer

Annals of Oncology, 3/02

Studies of Older Women

J Surg Onc, 11/02

Risks of Axillary Dissection Outweigh Benefits:Older women
Population-based Assessment of Hospitalizations:Toxicity
Tamoxifen vs MRM: NO SURVIVAL Difference
Long Term Outcomes in Older Women
Bca Survivors Less Risk for Heart Attacks
Simple Anesthesia/Simple Mastectomies
Hypertensive Meds & Bca Risk Elevated in Older Women
Oral Idarubicin (Mets BCa):Bad for Elderly Women
Elder Pts Want to KNOW about Disease/Treatment
Medicare Information, September 2004
Younger Women & Breast Cancer

Articles, studies, LINKS

Incidence/Prognosis-Early Onset Bca
Accuracy of Breast Imaging in Young Women
Impact of Surgery & Chemo on QOL of Younger Women
Treatment/Prognosis:Young Women
"Why I Wore Lipstick to My Mastectomy"
Dvlpmnt research agenda focused on breast ca women 40 years of age & under
Young Women Cancer Groups
Young Women w/DCIS not more likely to Recur

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